NFATc3 deficiency reduces the classical activation of adipose tissue macrophages
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چکیده
منابع مشابه
Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages
Obesity is characterized by adipose tissue (AT) macrophage (ATM) accumulation, which promotes AT inflammation and dysfunction. Toll-like receptor 4 (TLR4) deficiency attenuates AT inflammation in obesity but does not impede the accumulation of ATMs. The purpose of the current study was to determine whether TLR4 deficiency alters ATM polarization. TLR4(-/-) and wild-type mice were fed a low-fat,...
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Objective: Macrophage accumulation in adipose tissue (AT) during obesity contributes to inflammation and insulin resistance. Recruitment of monocytes to obese AT has been the most studied mechanism explaining this accumulation. However, recent evidence suggests that recruitment-independent mechanisms may also regulate pro-inflammatory AT macrophage (ATM) numbers. The role of increased ATM survi...
متن کاملActivation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment
OBJECTIVE Macrophage accumulation in adipose tissue (AT) during obesity contributes to inflammation and insulin resistance. Recruitment of monocytes to obese AT has been the most studied mechanism explaining this accumulation. However, recent evidence suggests that recruitment-independent mechanisms may also regulate pro-inflammatory AT macrophage (ATM) numbers. The role of increased ATM surviv...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2018
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-18-0070